THE SIR2-SUM1 COMPLEX REPRESSES TRANSCRIPTION USING BOTH PROMOTER-SPECIFIC AND LONG-RANGE MECHANISMS TO REGULATE CELL IDENTITY AND SEXUAL CYCLE IN THE YEAST KLUYVEROMYCES LACTIS.

Deacetylases of the Sir2 family regulate lifespan and response to stress.We have examined the evolutionary history of Sir2 and Hst1, which arose by gene duplication in budding yeast and which participate in distinct mechanisms of gene repression.In Saccharomyces cerevisiae, Sir2 interacts with the SIR complex to generate long-range silenced Coffee

Understanding, promoting and managing sustainable urban mobility better is very critical in the midst of an unprecedented climate crisis.Identifying, evaluating, benchmarking and prioritising its key indicators is a way to ensure that policy-makers will develop those transport strategies and measures necessary to facilitate a more effective transit

The case report describes a 16-year-old female with a ventriculoperitoneal (VP) shunt due to congenital hydrocephalus.She presented with abdominal pain and vaginal leakage of cerebrospinal fluid (CSF).CT imaging demonstrated multiple intra-abdominal and pelvic CSF pseudocysts as well as possible erosion of the VP shunt into the vagina.She was taken